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Cyanidin-3-O-Glucoside (C3G) facilitates the transition of microglia from the M1 to the M2 phenotype by activating the PPAR signal pathway and enhancing the phagocytosis of A42 by upregulating TREM2, thereby facilitating the clearance of accumulated -amyloid (252)

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doi: 10.3389/fcell.2025.1702720 Received 10 September 2025 Revised 13 October 2025 Accepted 20 October 2025 Published 10 November 2025 Volume 13 - 2025 Edited by Tao Zhang, Memorial Sloan Kettering Cancer Center, United States Reviewed by Xiaoyi Zhang, Jacobi Medical Center, United States Ying Chen, University of Texas MD Anderson Cancer Center, United States Updates Copyright 2025 Zhang, Qi and Chen